Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder.

Ann Med · 2026 · PMC12794707 · PMID 41508567

Europe PMC DOI

hedged sentence

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

did not reach statistical significancep = 0.053so close (0.05 < p ≤ 0.1)

In females, the dimLD aCSF-treated groups had somewhat longer sleep bouts compared to the dimLD OXA-treated and brLD aCSF-treated group during the day, but this difference did not reach statistical significance ( Figure 3B , F 2,19 = 3.48, p = 0.053).

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