Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake.

Furthermore, there is a clear trend apparent where cells in which Aft1 translocated to the nucleus later in their lifespan tended to live longer ( Figure 4C ).

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This is only slightly greater than the number of genes expected to overlap between the SSD1-V and CR datasets by chance and is in contrast to the highly significant overlap in transcriptional changes observed between CR and HAP4 overexpression (Lin et al. 2002) or between CR and high external osmolarity (Kaeberlein et al. 2002).

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