Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome.

Although this pattern of inconsistent mediation did not reach statistical significance in the Sobel test, it suggests that IL‐1RA may influence susceptibility to SS through competing biological pathways.

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Fourth, although the Sobel test did not achieve significance, likely due to sample size limitations inherent to two‐step MR, the effect estimates themselves warrant mechanistic hypotheses deserving further exploration.

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