Current and future perspectives on radioligand therapy in advanced prostate cancer.

59 Data in PCa cohorts treated with PSMA-RLT is emerging, with a clear trend that RLT may lead to development of new CH clones or expansion of existing CH clones, particularly in DNA-damage response genes such as PPM1D and TP53 ; the long-term implications of such clonal emergence or expansion is unclear, but will likely have more impact as RLT is moved earlier in the PCa d

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