High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial.

JAMA Intern Med · 2026 · PMC12797130 · PMID 41525066

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0.0700

closest p · 1.4× alpha

0.0700

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The sentences

did not reach statistical significanceP = .07so close (0.05 < p ≤ 0.1)

Incident diabetes-related complications in the overall population were numerically lower in the HD-IIV group but did not reach statistical significance (147 of 162 417 participants [0.1%] in the HD-IIV group vs 181 of 162 450 participants [0.1%] in the SD-IIV group; rVE, 18.8%; 95% CI, −1.5% to 35.1%; P = .07).

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