Western blot analysis indicated an increasing trend in VEGFA expression in the Au NPs@ZIF-8/Ga group, although the difference was not statistically significant.
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Bioengineered hollow nanoflowers to synergistically modulate inflammation, angiogenesis and osteogenesis for enhancing repair of bone defects.
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Western blot analysis showed that the phosphorylation level of IKKα/β (expressed as the p-IKKα/β to total IKKα/β ratio) exhibited a downward trend in the Ga and Au NPs@ZIF-8/Ga groups compared with the LPS control, although the differences did not reach statistical significance (Fig. 3 G).The expression of IκBα was higher in Ga and Au NPs@ZIF-8/Ga groups compared to the LPS group, though not fully restored to the level of the negative control, suggesting that these treatments partially protected IκBα from degradation (Fig. 3 D).