The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes.

On the other hand, intracellular protein levels of podocyte-associated molecules as quantified by semiquantitative computerized image analysis were significantly reduced when podocytes were subjected to high glucose condition (although the change in podocalyxin level did not reach statistical significance), while Dapagliflozin, Roxadustat, or their combination restored their intracellular protein levels (Fig. 2 ).

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