Statistical analyses To align with our primary research objective (i.e., how infections might impact longitudinal changes in brain structure), and secondary research objectives (i.e., whether such infection-related brain atrophy can influence cognitive decline and molecular changes underlying dementia), a hierarchical gating approach was employed, whereby infections of interest for downstream analyses were first identified with discovery analyses of infection-related brain volume loss in the BLSA using a nominally significant p-value of 0.05 (although FDR-corrected results are also presented) [ 19 ].
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Post-infection brain atrophy accelerates cognitive and molecular changes underlying dementia.
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