Nomogram for reducing unnecessary biopsies of breast lesions based on MRI and clinical features: a multi-center retrospective cohort study.

Cancer Imaging · 2025 · PMC12797689 · PMID 41353399

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0.0680

closest p · 1.4× alpha

0.0680

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did not reach statistical significancep = 0.068so close (0.05 < p ≤ 0.1)

These values were higher than those of BI-RADS when using the threshold > 3 (0.368 [95% CI: 0.284–0.459] in training set and 0.389 [95% CI: 0.231–0.565] in test set), and led to reductions of 12.8% (16/125) and 25% (9/36) unnecessary biopsies, although the specificity improvements did not reach statistical significance via the McNemar test ( p = 0.068 and p = 0.078, respectively).

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