Surgical vs Transcatheter Aortic Valve Replacement for Asymptomatic Severe Aortic Stenosis- an Updated Meta-Analysis of Reconstructed Individual Patient Data.

Interdiscip Cardiovasc Thorac Surg · 2026 · PMC12798724 · PMID 41442457

Europe PMC DOI

hedged sentences

0.1400

closest p · 2.8× alpha

0.1800

boldest claim

The sentences

did not reach statistical significanceP = .14not close (p > 0.1)

In subgroup analysis, the effect was mainly driven by observational studies (IRR = 0.37, 95% CI 0.27-0.50; P < .001), whereas the RCT subgroup did not reach statistical significance (IRR = 0.66, 95% CI 0.38-1.14; P = .14) ( Figure 1 ).

also in 111,027 other papers

a nonsignificant trendP = .18not close (p > 0.1)

This effect was predominantly derived from observational studies (IRR = 0.37, 95% CI 0.21-0.66; P < .01), while the RCT subgroup showed a nonsignificant trend (IRR = 0.63, 95% CI 0.32-1.24; P = .18) ( Figure 2A ).

also in 5,406 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.