Although the association did not consistently reach statistical significance in all subgroups and exhibited borderline significance in some cases, metabolic syndrome overall demonstrated a positive association with intrahepatic or extrahepatic cholangiocarcinoma risks, with HRs above one compared to nonmetabolic syndrome individuals.
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Associations between metabolic syndrome and cholangiocarcinoma risk: A large-scale population-based cohort study.
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The sentences
Both prediabetes and diabetes were associated with an increased risk of both intrahepatic and extrahepatic cholangiocarcinoma, showing a significant trend compared to those with normal fasting glucose levels.
In contrast, elevated triglyceride levels were not significantly associated with cholangiocarcinoma risk but showed a borderline significant association with intrahepatic cholangiocarcinoma.