Severe acute respiratory syndrome coronavirus 2-mediated dysregulation of drug processing genes is dependent on pathogenic variants, target site of infection, age, and sex.

Overall, there is a marked trend of increased NFKB1 expression across all variants, especially with the P.1 and Delta variants, whereas BA.1 and BA.2 uniquely induces a decrease in NFKB1 expression in the lung tissues ( Fig. 1 ).

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