Systemic cyst(e)inase administration induces ferroptosis and synergizes with temozolomide in glioblastoma.

iScience · 2026 · PMC12799779 · PMID 41541699

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a significant trendno p-value reported

Similarly, Mayo-6 cells showed a significant trend, with cristaeless mitochondria rising from 25.25% (25/99) to 57.52% (65/113).

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highly significantno p-value reported

This synergy was particularly evident in the TMZ-resistant GSC08387 model, where the combination led to a substantial and highly significant increase in survival, with up to 25% remission in the combination group.

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