LYN mutations in breast cancer: hypothesis-generating evidence for an association with central nervous system metastasis and domain-level insights.

Within LYN-mutant cases, an exploratory domain analysis indicated that distributions differed by CNS status (omnibus χ2 p ≈ 0.014); a one-versus-rest signal at the SH4/Unique N-terminus was nominally significant and borderline after false discovery rate (FDR) (unadjusted p ≈ 0.010; q ≈ 0.052; small in-domain n = 3).

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