Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial.

J Headache Pain · 2026 · PMC12801661 · PMID 41519709

Europe PMC DOI

hedged sentence

0.0910

closest p · 1.8× alpha

0.0910

boldest claim

The sentences

did not reach statistical significancep = 0.091so close (0.05 < p ≤ 0.1)

The mean within-subject difference was + 266 bpm * min (95% CI: -145 to + 676), which did not reach statistical significance (paired t-test, p = 0.091).

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