Putative breast cancer risk variants from populations of South Asian ancestry are under-represented in public variant classification databases.

The power of per-gene testing was constrained by sample size, but results were highly significant (Fisher Exact p-value < 2.2e-16) when variants were combined across all genes [Table S8].

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Accounting for total numbers of observed variants from gnomAD, the difference was nominally significant (unadjusted Fisher Exact p-value < 0.05) in 7 of the 9 genes, and exceeded the Bonferroni multiple hypothesis testing threshold (p < 0.0014) in 3 genes ( PALB2 , ATM , BRCA2 ) [Table S5].

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