The ratio of GGT to PLT indices is a predictive factor for the progression of liver fibrosis in NA-treated chronic hepatitis B patients with advanced fibrosis plus PEG-IFN α-2a therapy: a case-control study.

Compared to the null model (which included only the intercept term, assigning all patients the same baseline risk of 23.2%), the 24-week GPR model demonstrated highly significant reclassification improvement.: continuous NRI = 0.972 (95% CI: 0.000–1.160, P = 0.008), categorical NRI = 0.486 (95% CI: 0.259–0.711, P < 0.001), IDI = 0.024 (95% CI: 0.010–0.040, P = 0.002).

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While the GGT level at 24 weeks of interferon therapy demonstrated a relatively high AUC, it did not reach statistical significance ( P = 0.055).

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