Impact of COVID-19 on Invasive Pneumococcal Disease: A Comparative Analysis of Clinical Features and Antibiotic Resistance across Pandemic Periods.

Within vaccine failure cases specifically, comorbidities were present in 7/19 (36.8%) of pre-pandemic cases compared to 13/26 (50.0%) of pandemic-era cases ( P =0.380), though this difference did not reach statistical significance. The antibiotic susceptibility patterns of cultured isolates are detailed in Table 3 .

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