Comparison of Efficacy and Safety between Anterior Cisterna and High Cervical Intrathecal Drug Delivery for Craniofacial Cancer Pain: A Multicenter Retrospective Cohort Study.

Pain Ther · 2026 · PMC12804447 · PMID 41288898

Europe PMC DOI

hedged sentences

0.0720

closest p · 1.4× alpha

0.0720

boldest claim

The sentences

a nonsignificant trendP = 0.072so close (0.05 < p ≤ 0.1)

The AC group experienced significantly more procedure-related complications, particularly postdural puncture headache (18.2% versus 4.5%, RR: 4.00; 95% CI 1.07–14.97; P = 0.024), with a nonsignificant trend toward higher CSF leakage (12.1% versus 3.0%, P = 0.072).

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did not reach statistical significanceno p-value reported

Although these differences did not reach statistical significance in our cohort, they aligned with the neuroanatomical reality that high cervical catheter placement brings opioids closer to brainstem respiratory centers [ 21 ].

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