Barely Significant
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Impact of Alpha-mangostin on human esophageal adenocarcinoma cells reveals activation of key apoptotic signaling pathways.

Discov Oncol · 2025 · PMC12804520 · PMID 41369822

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a clear trendno p-value reported
A clear trend in increase in Caspase + populations was observed (Fig. 4 A).

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highly significantno p-value reported
The effect on colony formation was highly significant at 10 μM (Fig. 2 B). α-Mangostin induces apoptosis in OE33 cells To explore the mechanism underlying the anti-proliferative effect of α-Mangostin, Annexin V & Dead Cell Assay was performed.

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an increasing trendno p-value reported
This is all the more important as studies on patients with esophageal cancers revealed an increasing trend in the incidence of esophageal adenocarcinoma [ 6 , 7 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.