A clear trend in increase in Caspase + populations was observed (Fig. 4 A).
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Impact of Alpha-mangostin on human esophageal adenocarcinoma cells reveals activation of key apoptotic signaling pathways.
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The effect on colony formation was highly significant at 10 μM (Fig. 2 B). α-Mangostin induces apoptosis in OE33 cells To explore the mechanism underlying the anti-proliferative effect of α-Mangostin, Annexin V & Dead Cell Assay was performed.
This is all the more important as studies on patients with esophageal cancers revealed an increasing trend in the incidence of esophageal adenocarcinoma [ 6 , 7 ].