Gut microbiome composition influences immunologic alterations in the blood and gut of HIV-positive and HIV-negative men who have sex with men.

Front Immunol · 2025 · PMC12808405 · PMID 41550925

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a trend toward significancep =0.06so close (0.05 < p ≤ 0.1)

Adonis showed a significant difference with MSM status (unweighted p=0.002, weighted p=0.001) and a trend toward significance with HIV status (unweighted p =0.06; adonis with formula: distance matrix ~ MSM-status + HIV-status).

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did not reach statistical significanceno p-value reported

As expected, CD4 + T cell frequencies in both blood and colon were reduced in HIV + MSM compared to the other cohorts ( Supplementary Figure 2 ), though this did not reach statistical significance.

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