Temporal dynamics of SARS-CoV-2 antibodies and IgG subclasses following multiple doses and diverse COVID-19 vaccine combinations.

However, this reduction did not reach statistical significance in the other groups.The neutralization assay provided both qualitative and quantitative insights, allowing evaluation of neutralizing antibody (NAb) seropositivity across different VoCs and at three distinct time points: after completion of the primary two-dose vaccination series ( Figures 3A–D ), six months post-second dose ( Figures 3E–J ), and following booster vaccination ( Figures 3K–P ).

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