Beta-cell-specific C3 deficiency exacerbates metabolic dysregulation and insulin resistance in obesity.

In a second experimental cohort of mice, focusing on earlier time points, a significant decrease in the QUICKI measurement of insulin sensitivity developed with time in HFD fed beta-C3-KO mice, and became significantly worse compared to control HFD mice already at 9 weeks ( Figure 5 E), while HOMA2-%B showed a trend towards an increase in the HFD fed beta-C3-KO mice at 9 and 12 weeks ( Figure 5 F).

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