A causal coding variant regulating alternative splicing of <i>DOC2A</i> at 16p.11.2 GWAS locus influences susceptibility to schizophrenia.

4B ), while the percentage of distance traveled in the closed arms showed a trend increase, but the difference was not statistically significant (control, 79.61 ± 2.94% distance in closed arms; DOC2A ∆ Val217-Pro218 , 86.14 ± 2.04% distance in closed arms; DOC2A ∆Val217-Pro218 versus control, P = 0.07, t = 1.84, df = 42; multiple comparisons using Fisher’s LSD in a one-way ANOVA; Fig. 4B ) compared to the control mice.

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