Genomic profiling of active vitamin D colonic responses in African- and European-Americans identifies an ancestry-related regulatory variant of POLB.

We also performed overlap analysis with an eQTL mapping study that identified four reQTL in 1,25D treatment in peripheral blood from African Americans and found that rs3848646- LCCR25 had nominally significant fastQTL p-value in 1,25D (p = 0.011) but not in EtOH (p = 0.228), suggestive of replication.

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The SNP rs12672468, for example, had a pm in control treatment not significantly different from zero (pm = -5.9x10 -4 ; lfsr = 0.497), while it had a highly significant pm in 1,25D (pm = -0.594; lfsr = 4.34x10 -13 ; S5c and S5d Fig ).

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