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Poly(A) variants supporting robust transmission stability in bacteria and high protein expression in animals for mRNA <i>in vitro</i> transcription.

Mol Ther Nucleic Acids · 2026 · PMC12811438 · PMID 41552384

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Furthermore, the RG2 variant supported higher luciferase activity than RG1 (1.3-fold increase; p = 0.08, Student’s t test), as well as relative to the A60-60 and A60-G-A60 variants, though these differences did not reach statistical significance.

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