Shared signatures of alcohol-associated dysbiosis in humans and non-human primates.

Notably, the SCFA-producing function exhibited a complex regulatory pattern in alcohol use disorder (AUD): although traditional beneficial bacteria such as Faecalibacterium prausnitzii and Akkermansia were generally reduced, certain SCFA producers such as Coprococcus showed an increasing trend in AUD.

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Of particular interest, among the 11 microbial markers exhibiting consistent differential abundance patterns, two phylum-level taxa— Verrucomicrobia and Actinobacteria , both of which encompass important SCFA producers—showed a decreasing trend, which is consistent with findings from previous clinical studies ( Everard et al., 2013 ; Png et al., 2010 ; Dethlefsen and Relman, 2011 ).

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The abundances of Blautia and Coprococcus were significantly increased in AUD patients and showed a trend of increase in those with chronic alcohol consumption. 3.5 Clinical phenotypic abnormalities are associated with gut microbiota dysbiosis Correlation analyses were conducted between common differential microbiota identified in Section 3.4 and clinical phenotypic abnormalities.

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