Germline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors.

Acta Neuropathol · 2026 · PMC12812103 · PMID 41546701

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Gliomas from SDHA GV carriers with less DSB accumulation showed a trend towards a higher mean nuclear IRS of RAD51 than those from ATM , BRCA2, and FANCA GV carriers with more DSBs (Fig. 4 c, d).

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