Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk.

Nonetheless, a positive trend was also observed for the association between the PRS WMH and DBP ( ꞵ = 0.070 [−0.001, 0.140], p = 0.051) and MAP ( ꞵ = 0.067 [−0.002, 0.136], p = 0.058), although results did not reach statistical significance ( Supplementary Table 8 ).

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HR ( ρ = 0.071 [−0.003, 0.145], p = 0.06) and PP ( ρ = 0.041 [−0.032, 0.112], p = 0.272) showed the same positive trend, but results did not reach statistical significance ( Table 4 ; Figure 4A ).

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