Consistent with the univariate analysis, the multivariate Cox analysis confirmed that older age (>65), female sex were significant negative prognostic factors, with N3 status showing a trend towards significance ( Figure 3E ).
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Beyond tumor mutation burden: tumor neoantigen burden as a superior prognostic biomarker in resected gastric cancer.
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Despite showing a numerical trend toward better overall survival, TMB failed to reach statistical significance at both timepoints (median follow-up period of 23.5 and 35.5 months) ( Figures 3A, B ).