Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.

Mol Psychiatry · 2026 · PMC12815664 · PMID 40830579

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nominally significantno p-value reported

Those associations were identified as potentially causal association if: (1) IVW/contamination mixture test was FDR-significant, (2) confirmed by nominally significant weighted median results in the same direction of IVW and (3) nominally significant MR Egger analysis if there was any horizontal pleiotropy indicated by an Egger intercept significantly deviating from zero.

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