Integrative multi-omics stratification and translational evaluation of Treg-targeted combination immunotherapy in breast cancer.

Front Oncol · 2025 · PMC12815797 · PMID 41568381

Europe PMC DOI

hedged sentence

0.2430

closest p · 4.9× alpha

0.2430

boldest claim

The sentences

did not reach statistical significancep = 0.243not close (p > 0.1)

Although the interaction term in two-way ANOVA did not reach statistical significance (p = 0.243; n=5 per group), the collective evidence from multiple efficacy endpoints supports a cooperative effect of CCR8 blockade in enhancing the response to PD–L1 inhibition in the immunosuppressive EMT6 tumor model.

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