Integrated proteomics and metabolomics analysis revealed that macrophage-related signals may be potential biomarkers for oral squamous cell carcinoma.

It is noteworthy that while ARPC4 showed promise in univariate analysis, it failed to reach statistical significance as an independent predictor in the multivariate Cox regression model; this could be a consequence of the relatively small sample size, which may limit the statistical power to detect independent effects (Supplementary·Figure 3 ).

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