Barely Significant
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Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis.

Sci Rep · 2026 · PMC12816732 · PMID 41526530

Europe PMCDOI
1
hedged sentence
0.0039
closest p · 0.1× alpha
0.0039
boldest claim

The sentences

did not reach statistical significancep = 0.0039actually significant
In NC114-treated hearts, both genes were significantly downregulated at 1 week post-TAC, whereas at 4 weeks they exhibited downward trends that did not reach statistical significance (log2FC = –1.99 and –3.18; adj. p = 0.0039 and 0.0179 at 1 week; log2FC = –1.16 and –3.20; adj. p = 0.0722 and 0.0529 at 4 weeks; data from Supplementary Materials, RNAseq_NCVH_1wk.xlsx and RNAseq_NCVH_4wk.xlsx).

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