Triazole-(<i>p</i>-tolylthio)methyl hybrids <i>via</i> click chemistry: synthesis, molecular docking, and evaluation as promising anticancer candidates.

RSC Adv · 2026 · PMC12818029 · PMID 41568211

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0.0010

closest p · 0.0× alpha

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boldest claim

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highly significantp < 0.001actually significant

Statistical comparison to doxorubicin using one-way ANOVA with Dunnett's post hoc test revealed that the superior activity of most compounds against HepG-2 cells was highly significant ( p < 0.001, Table 1 ).

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a clear trendno p-value reported

3.5.1 Influence of lipophilicity and long alkyl chains A clear trend emerges when correlating antiproliferative activity with lipophilicity (expressed as MiLogP).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Triazole-(&lt;i&gt;p&lt;/i&gt;-tolylthio)methyl hybrids &lt;i&gt;via&lt;/i&gt; click chemistry: synthesis, molecular docking, and evaluation as promising anticancer candidates.

The sentences

Triazole-(<i>p</i>-tolylthio)methyl hybrids <i>via</i> click chemistry: synthesis, molecular docking, and evaluation as promising anticancer candidates.