Temporal trends in progression risk in smoldering myeloma: a systematic review.

EClinicalMedicine · 2026 · PMC12818083 · PMID 41567715

Europe PMC DOI

hedged sentences

0.2720

closest p · 5.4× alpha

0.2720

boldest claim

The sentences

did not reach statistical significancep = 0.272not close (p > 0.1)

Studies enrolling most patients before 2014 showed higher progression rates than in more recent cohorts (Spearman's rho = 0.645, p = 0.034), but this trend did not reach statistical significance in high-risk groups (rho = 0.360, p = 0.272).

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highly significantno p-value reported

Despite these limitations, the differences in outcomes for patients enrolled between 1970 and 2024 remain statistically highly significant.

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