Comparative effects of pharmacological interventions in the prophylactic treatment of tension-type headache: systematic review and network meta-analysis.

Also, there was a favorable trend for amitriptyline 75 mg (8 weeks: −2.87 days), but the quality of evidence was low, and the credible intervals were wide.

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At 12 and 24 weeks, amitriptyline 100 mg showed a trend toward reduction in headache days, but the 95% CrI was wide and crossed zero with very low certainty of evidence (12 weeks: MD −5.62, 95% CrI −13.19 to 2.50; 24 weeks: MD −5.12, 95% CrI −12.28 to 4.71, Figure 3 and Table S6 ).

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