Impact of Elexacaftor-Tezacaftor-Ivacaftor on Gastrointestinal Symptoms, Intestinal Ultrasound, and Pancreatic Stiffness in Cystic Fibrosis.

Clin Transl Gastroenterol · 2026 · PMC12818862 · PMID 41134303

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borderline significantno p-value reported

In addition, the presence of IICs was linked to changes in stool frequency and form/consistency, with a borderline significant correlation with intestinal intussusception.

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showed a trendno p-value reported

This parameter showed a trend to increase with a median of 203 (interquartile range [IQR] 190–469) at T0 and 438 (IQR 110–500) at T12, without reaching statistical significance ( P = 0.812), but a clinically relevant improvement (>500 μg/g feces) was observed in 2 patients (16 and 17 years old) after 12 months on ETI therapy.

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