By carvedilol dose When studies were stratified according to carvedilol dosage, six studies using 12.5 mg/day showed a trend favoring carvedilol ( SMD = −0.24 [95 % CI: −0.54, 0.05], I 2 = 59 % ), whereas studies using > 12.5 mg/day also favored carvedilol ( SMD = –0.18 [95 % CI: −0.50, 0.14], I 2 = 46 % ).
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The efficacy of carvedilol in improving cardiac function and survival in patients with anthracycline-induced cardiotoxicity: a comprehensive systematic review and meta-analysis.
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