Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery.

Prolonged preoperative alpha-blockade was also associated with longer hypertensive crisis episodes in the overall cohort (ρ = 0.77, p < 0.01; Table 3 ; Figures 1A, B ), although this correlation did not reach statistical significance in the PXB subgroup ( Figure 1C ).

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