Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF-induced trained immunity.

Front Immunol · 2025 · PMC12819694 · PMID 41573556

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did not reach statistical significanceno p-value reported

Inhibition of LXR signaling significantly reduced TNFα production in GM-CSF trained cells, while the decrease in IL-6 levels did not reach statistical significance ( Figures 6C, D ).

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