A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN<sup>+</sup>) Product for Male Facial Skin: Effects on Skin Appearance and Properties.

Skin Res Technol · 2026 · PMC12821225 · PMID 41562471

Europe PMC DOI

hedged sentences

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

a decreasing trendp = 0.13not close (p > 0.1)

Additionally, the ΔE1 parameter, reflecting color differences, revealed a decreasing trend in the cheek area for the GEN + group, with a statistically significant difference observed with PP analysis (ITT: MD = –0.39, 95% CI: –0.89 to 0.12, p = 0.13; PP: MD = –0.56, 95% CI: –1.06 to –0.06, p = 0.03), suggesting improved color consistency (Figure 2 ).

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did not reach statistical significanceno p-value reported

While the melanin index showed a decreasing trend across most facial areas, the change did not reach statistical significance.

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