Effective serum concentration of high-dose methotrexate therapy for osteosarcoma with dose adjustment for pharmacokinetic parameters: a retrospective study.

In contrast, there was a significant difference in OS between patients with C mean(1−6) -H and those with C mean(1−6) -L, and a significant trend was observed in the EFS ( p = 0.010 and 0.061, respectively; log-rank test).

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