A novel statistical feature selection framework for biomarker discovery and cancer classification via multiomics integration.

BMC Med Res Methodol · 2025 · PMC12822226 · PMID 41408184

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a clear trendno p-value reported

Although Stage I and Stage II samples exhibited partial overlap, a clear trend of separation along PC1 was observed, indicating that the selected features preserved biologically meaningful stage-related variance.

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borderline significantno p-value reported

In TCGA-LUAD, SFTA3 showed a highly protective effect (HR = 0.73, p < 1e-06), while ACPP (HR = 0.83, p = 0.010) and SOX2OT (KM borderline significant) also stratified patient outcomes.

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