PD-L1 on Tumor-Derived Extracellular Vesicles Induces CD8<sup>+</sup> T Cell Terminal Exhaustion and Mediates Anti-PD-1 Resistance in Head and Neck Squamous Cell Carcinoma.

Moreover, a consistent trend was observed in subgroups with CPS = 0, CPS ≥ 20, and p16‐negative disease, although these differences did not reach statistical significance, likely due to the limited sample size within these specific cohorts (Figure S2 , Supporting Information).

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