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Emerging Therapies in IgA Nephropathy: From A Proliferation-Inducing Ligand (APRIL) and B-cell Activating Factor (BAFF) Inhibitors to Precision Medicine.

Cureus · 2025 · PMC12823202 · PMID 41573494

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Although the primary endpoint of proteinuria reduction did not reach statistical significance, a trend toward decreased proteinuria over 12 months was observed, suggesting potential clinical benefit in subsets of patients with higher complement activation.

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