A Mechanism-Based Multi-Level Population PK/PD Model for Potassium-Competitive Acid Blockers.

CPT Pharmacometrics Syst Pharmacol · 2026 · PMC12823312 · PMID 41540745

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showed a trendno p-value reported

In addition, the SCALE parameter, which defines the pH level associated with maximal absorption in the feedback function, showed a trend that was broadly consistent with known pKa values for the PCABs.

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