Protection Against Type 1 Diabetes Development in Mice With 4E-BP2 Deletion.

1 D and E ), which showed a trend toward a decreased proinsulin-to-insulin ratio in Eif4ebp2 −/− mice ( P = 0.076).

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NOD.SCID mice that received Eif4ebp2 −/− nondiabetic lymphocytes exhibited significantly lower fasting glucose levels when compared with the control diabetic lymphocyte group and a tendency toward significance when compared with the Eif4ebp2 −/− diabetic lymphocyte group ( Fig. 4 D ). β-Cell mass was low in all groups, except in the mice that received Eif4ebp2 −/− nondiabetic lymphocytes ( Fig. 4 E ), in which the highest diabetes free incidence was seen ( Fig. 4 B ).

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