Dissecting the genetic and proteomic risk factors for delirium.

Nat Aging · 2026 · PMC12823428 · PMID 41286463

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0580

boldest claim

The sentences

highly significantP = 2.7 × 10 −141actually significant

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

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nominally significantP = 0.013actually significant

In our study, CR1 plasma protein levels had a nominally significant association with incident delirium ( P = 0.013).

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marginally nonsignificantP = 0.058so close (0.05 < p ≤ 0.1)

Four out of five of the lead replicated MTAG signals were also significant in the original delirium GWAMA (Supplementary Table 3 ), with rs2279590 ( CLU gene) being marginally nonsignificant ( P = 0.058).

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