A robust ammonia metabolism gene signature identified by machine learning predicts prognosis and immunotherapy response in clear cell renal cell carcinoma.

Front Oncol · 2025 · PMC12823514 · PMID 41584585

Europe PMC DOI

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closest p · 1.0× alpha

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failed to reach statistical significancep > 0.05actually significant

In the internal validation cohort, the Kaplan-Meier curve failed to reach statistical significance (p > 0.05) for stratifying patient OS, with relatively low AUC values further evidencing limited predictive efficacy.

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